Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
Folic acid restricts SARS-CoV-2 invasion by methylating ACE2
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The current COVID-19 pandemic is motivating us to demonhorns edge elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility.We found that SARS-CoV-2 could increase the protein level of ACE2 in mice.Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promoter and inhibit ACE2 expression.Folic acid treatment decreased the binding ability of Spike protein, pseudovirus and inactivated authentic SARS-CoV-2 to host cells.
Thus, folic acid treatment could decrease SARS-CoV-2 invasion and SARS-CoV-2-neutralizing antibody production in mice.These data suggest that increased intake of folic acid may inhibit ACE2 expression and reduce the transmissibility of SARS-CoV-2.Folic acid could play an israil iphone 14 pro max important role in SARS-CoV-2 infection prevention and control.